Compound ID | 2382
Harundomycin A
Class: Natural product antibiotic
| Agent Type: | Natural product; Direct acting; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Fatty acid synthesis inhibitor. FabF inhibitor |
| Target Pathogen: | Active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci |
| Description: | Natural product from combined cultures of Streptomyces hygroscopicus HOK021 and Tsukamurella pulmonis TP-B0596 (not detected in mono-cultures); no cytotoxicity against HeLa cells (up to 128 uM vs MIC 16-32 uM) |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acschembio.2c00585 |
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