Compound ID | 2387

Update compound information

TXH9179

Synonym(s): TXH-9179  |  GLXC-27037

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell division inhibitor. FtsZ inhibitor
Target Pathogen: Active against methicillin-sensitive and methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, and linezolid-resistant Staphylococcus aureus
Description: Synthetic compound; no cytotoxicity against opossum kidney (mammalian) cell line at 4x and 10x MIC; its carboxamide prodrug is TXH1033
Institute where first reported: Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, United States
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 345.33
Iso. SMILES: C#CC1=CC2=C(N=C1)SC(=N2)COC3=C(C(=C(C=C3)F)C(=O)N)F
InChI Key: SCUOMBYZGFZRIF-UHFFFAOYSA-N
Can. SMILES: C#CC1=CC2=C(N=C1)SC(=N2)COC3=CC=C(C(=C3F)C(=O)N)F
InChI: InChI=1S/C16H9F2N3O2S/c1-2-8-5-10-16(20-6-8)24-12(21-10)7-23-11-4-3-9(17)13(14(11)18)15(19)22/h1,3-6H,7H2,(H2,19,22)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/167312464
Citation: https://pubs.acs.org/doi/10.1021/acschembio.2c00934

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