Compound ID | 2389
Cyclic temporin L peptide 12
Class: Antimicrobial peptide
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Membrane-active agent |
| Target Pathogen: | Active against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus, S. epidermidis, Bacillus megaterium, and Acinetobacter baumannii |
| Description: | Synthetic compound based on natural product temporin L from red frog Rana temporaria; lactam stapled peptide; cytotoxicity against HaCat cells showed 94% and 60% viability at 25 uM and 50 uM respectively vs 1.56-3.12 MIC |
| Year first mentioned: | 2021 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01033 |
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