Compound ID | 2390
5-amino-4-quinolone 111
Synonym(s): 5-aminoquinolin-4-one 111
Class: Quinolone
| Spectrum of activity: | Gram-positive |
| Details of activity: | Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Enterococcus faecium; disrupts integrity of cytoplasmic membrane |
| Description: | Synthetic compound; analogues and derivatives with antibacterial property reported; no haemolysis observed against sheep erythrocytes at 32 ug/ml vs MIC at <0.0625 ug/ml; LDH level to indicate cytotoxicity towards Vero cells only at 20% at highest concentration tested (30 uM) |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01151 |
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