Compound ID | 2392
Neolignan-AMP mimic conjugate III15
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Staphylococcus aures, methicillin-resistant Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Salmonella enterica; membrane-active agent (cytoplasmic membrane) |
| Description: | Synthetic compound with core that is an isomer of the natural product isomagnolone from llicium plants; shows 100% survivability of MRSA infection in mice when administered at 20mg/kg (comparable to vancomycin) |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01674 |
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