Compound ID | 240

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GPI0363

Class: RNA synthesis inhibitor

Spectrum of activity: Gram-positive
Details of activity: Compound 363 inhibited the growth of methicillin-resistant S. aureus and exhibited therapeutic effects in both silkworm and mouse infection models with low toxicity. Targets RNA polymerase sigma factor
Institute where first reported: Graduate Sch. Of Pharmaceitucl Sci. University of Tokyo, Japan
Year first mentioned: 2014
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 342.41
Iso. SMILES: CCCNC(N1CCC2(CC1)C3=CC=CN3C4=CC=C(F)C=C4N2)=O
InChI Key: RKUWYDRDGHPUCT-UHFFFAOYSA-N
Can. SMILES: CCCNC(=O)N1CCC2(CC1)C3=CC=CN3C4=CC=C(C=C4N2)F
InChI: InChI=1S/C19H23FN4O/c1-2-9-21-18(25)23-11-7-19(8-12-23)17-4-3-10-24(17)16-6-5-14(20)13-15(16)22-19/h3-6,10,13,22H,2,7-9,11-12H2,1H3,(H,21,25)
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/46357521
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403886/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403886/

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