Compound ID | 2401
Kaempferol-derived compound 52
Class: Small molecule antibacterial agent
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Membrane-active agent |
| Target Pathogen: | Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus |
| Description: | Synthetic compound based on the natural product kaempferol; high membrane selectivity, low cytotoxicity towards mammalian cells (>32x MIC); analogues with antibacterial property reported |
| Year first mentioned: | 2020 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00053 |
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