Compound ID | 2403
Aromatic-linked diamino acid AMP mimic 8j
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Stenotrophomonas maltophilia; membrane-active agent |
| Description: | Synthetic compound (peptidomimetic); cytotoxicity towards umbilical vein endothelial cells (HUVECs) at CC50 of 24.2 mg/L (vs control retapamulin 25.5 mg/L); <1% haemolysis of mammalian red blood cells even at 320 mg/L (MIC up to 4 mg/L) |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01583 |
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