Compound ID | 2406

Update compound information

6-pyrenyl PTM 6t

Class: Small molecule antibacterial agent

Agent Type: Semisynthetic; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Fatty acid synthesis inhibitor. FabF inhibitor
Target Pathogen: Active against Staphylococcus aureus, methicillin-sensitive Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus
Description: Synthetic compound, derivative of the natural product platensimycin from soil bacteria Streptomyces platensis; significantly reduced MRSA load in mice infection model; analogues reported
Year first mentioned: 2018
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 641.71
Iso. SMILES: OC1=C(NC(CC[C@]2(C)C(C(C3=CC=C4C5=C3C=CC6=C5C(C=C4)=CC=C6)=C[C@@]78C[C@@H]9C[C@@H](C72)O[C@@]9(C)C8)=O)=O)C(O)=CC=C1C(O)=O
InChI Key: CTFZGCXCAOPDDS-YHRLUSEXSA-N
Can. SMILES: C[C@]1(CCC(=O)NC2=C(C(=CC=C2O)C(=O)O)O)C3[C@@H]4C[C@H]5C[C@@]3(C=C(C6=C7C=CC8=CC=CC9=CC=C(C=C6)C7=C98)C1=O)C[C@]5(C)O4
InChI: InChI=1S/C40H35NO7/c1-38(15-14-30(43)41-33-28(42)13-12-26(34(33)44)37(46)47)35-29-16-23-17-40(35,19-39(23,2)48-29)18-27(36(38)45)24-10-8-22-7-6-20-4-3-5-21-9-11-25(24)32(22)31(20)21/h3-13,18,23,29,35,42,44H,14-17,19H2,1-2H3,(H,41,43)(H,46,47)/t23-,29-,35?,38-,39-,40+/m0/s1
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01580

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.