Compound ID | 2407
Imidazolidine-4-one derivative 3
Class: Antimicrobial peptide
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Membrane-active agent |
| Target Pathogen: | Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Klebsiella pneumoniae |
| Propensity to select resistant mutants: | Yes |
| Description: | Synthetic compound (peptidomimetic); haemolytic at HC50 >125x MIC and cytotoxic to HeLa cells at IC50 >38x MIC |
| Year first mentioned: | 2020 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00171 |
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