Compound ID | 2411

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Nonivamide derivative 51

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae; permeabilizes outer membrane and disrupts integrity of cytoplasmic membrane
Description: Synthetic compound; low haemolytic activity with HC50 approximately 21x MIC and low cytotoxicity towards mammalian cells
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 561.8
Iso. SMILES: N=C(N)NCCCCCCOC1=CC=C(CNC(CCCCCCCC)=O)C=C1OCCCCCCNC(N)=N
InChI Key: PADBGRLZVGGFPY-UHFFFAOYSA-N
Can. SMILES: CCCCCCCCC(=O)NCC1=CC=C(C(=C1)OCCCCCCNC(=N)N)OCCCCCCNC(=N)N
InChI: InChI=1S/C30H55N7O3/c1-2-3-4-5-6-11-16-28(38)37-24-25-17-18-26(39-21-14-9-7-12-19-35-29(31)32)27(23-25)40-22-15-10-8-13-20-36-30(33)34/h17-18,23H,2-16,19-22,24H2,1H3,(H,37,38)(H4,31,32,35)(H4,33,34,36)
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01604

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