Compound ID | 2413

Update compound information

3-(4-(cyclopentyloxy)phenyl)-5-(4-nitro-1H-imidazol-2-yl)-1,2,4-oxadiazole

Synonym(s): oxadiazole 57

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against Clostridium difficile; disrupts integrity of cytoplasmic membrane
Description: Synthetic compound; high selectivity (selectivity index >512)
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 341.32
Iso. SMILES: C1CCC(C1)OC2=CC=C(C=C2)C3=NOC(=N3)C4=NC=C(N4)[N+](=O)[O-]
InChI Key: YVGVVEXAXFXADS-UHFFFAOYSA-N
Can. SMILES: C1CCC(C1)OC2=CC=C(C=C2)C3=NOC(=N3)C4=NC=C(N4)[N+](=O)[O-]
InChI: InChI=1S/C16H15N5O4/c22-21(23)13-9-17-15(18-13)16-19-14(20-25-16)10-5-7-12(8-6-10)24-11-3-1-2-4-11/h5-9,11H,1-4H2,(H,17,18)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/169450098
Citations:
  • https://www.pnas.org/doi/10.1073/pnas.2304110120
  • https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01249

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