Compound ID | 2415

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1,3-Diamino-7H-pyrrol[3,2-f]quinazoline derivative

Synonym(s): PQD derivative 6r

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, and Acinetobacter baumannii
Propensity to select resistant mutants: Yes
Description: Synthetic compound; reduced bacterial load of MRSA infection in mouse thigh with better efficacy than trimethoprim
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 346.41
Iso. SMILES: NC1=NC(N)=NC2=C1C3=C(N(CC4=CC=C5SC=NC5=C4)C=C3)C=C2
InChI Key: WFHFOKYUKSODFR-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1CN3C=CC4=C5C(=CC=C43)N=C(N)N=C5N)N=CS2
InChI: InChI=1S/C18H14N6S/c19-17-16-11-5-6-24(14(11)3-2-12(16)22-18(20)23-17)8-10-1-4-15-13(7-10)21-9-25-15/h1-7,9H,8H2,(H4,19,20,22,23)
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00891

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