Compound ID | 2421

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Triazolylpyrimidinediol (triazolyl PD) 7a

Synonym(s): PD 7a

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against methicillin-resistant Staphylococcus aureus, Enterococcus faecalis, Staphylococcus aureus Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii; DNA-groove binder
Propensity to select resistant mutants: Y, low
Description: Synthetic compound (azolylpyrimidinediol); analogues reported; 85% viability of hepatocyte cells at 64x MIC
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 250.26
Iso. SMILES: C1=CN=C(N=C1N2C=NC=N2)N(CCO)CCO
InChI Key: LANWITCFEKLDEX-UHFFFAOYSA-N
Can. SMILES: C1=C(N=C(N=C1)N(CCO)CCO)N2C=NC=N2
InChI: InChI=1S/C10H14N6O2/c17-5-3-15(4-6-18)10-12-2-1-9(14-10)16-8-11-7-13-16/h1-2,7-8,17-18H,3-6H2
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c02042

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