Compound ID | 2423
Octapeptin C-02
Class: Lipopeptide
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent |
| Target Pathogen: | Active against Escherichia coli, carbapenem-resistant Escherichia coli, Pseudomonas aeruginosa, and carbapenem-resistant Pseudomonas aeruginosa |
| Description: | Synthetic compound based on natural product octapeptins (EM49) from Bacillus circulans; analogues and derivatives reported; selectivity index of 827.8 (HK-2 cells IC50 at 413 ug/ml vs MIC at 0.2-2 ug/ml) |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
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