Compound ID | 2426

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Halofuginone derivative 3

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Escherichia coli, Shigella flexneri, Salmonella typhi, and methicillin-resistant and -susceptible Staphylococcus aureus
Description: Synthetic compound based on the halogenated derivative of the natural product febrifugine from the herb Dichroa febrifuga
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 337.78
Iso. SMILES: FC1=C(Cl)C=C2N=CN(CC(C[C@H]3NCCCC3)=O)C(=O)C2=C1
InChI Key: LZMOBHASNVDDQN-JTQLQIEISA-N
Can. SMILES: C1CCN[C@@H](C1)CC(=O)CN2C=NC3=C(C=C(C(=C3)Cl)F)C2=O
InChI: InChI=1S/C16H17ClFN3O2/c17-13-7-15-12(6-14(13)18)16(23)21(9-20-15)8-11(22)5-10-3-1-2-4-19-10/h6-7,9-10,19H,1-5,8H2/t10-/m0/s1
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01496

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