Compound ID | 2430

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N-Aryl mercaptopropionamide 29

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against NDM-1 expressed by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Serratia marcescens
Description: Synthetic compound; analogues reported; synergistic effect with imipenem; low cytotoxicity towards HepG2, HEK293, A549 (<10%) at 100 uM
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 225.27
Iso. SMILES: C1=CC(=CC(=C1)NC(=O)CCS)C(=O)O
InChI Key: IMJQVWNXOWQSPB-UHFFFAOYSA-N
Can. SMILES: C1=CC(=CC(=C1)C(=O)O)NC(=O)CCS
InChI: InChI=1S/C10H11NO3S/c12-9(4-5-15)11-8-3-1-2-7(6-8)10(13)14/h1-3,6,15H,4-5H2,(H,11,12)(H,13,14)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/83773739
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01755

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