Compound ID | 2431

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Rifasutenizol

Synonym(s): Rifamycin-nitroimidazole conjugate  |  TNP-2198

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: RNA synthesis inhibitor. RNA polymerase inhibitor
Target Pathogen: Active against Helicobacter pylori and Clostridioides difficile
Description: Synthetic compound
Institute where first reported: TenNor Therapeutics Ltd, 218 Xinghu Street, Suzhou Industrial Park, Suzhou 215123, China
Year first mentioned: 2022
Highest development stage: Phase 3 (NCT05857163)
Development status: Active
Chemical structure(s):
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Molecular weight: 944.04
Iso. SMILES: C[C@H]1/C=C/C=C(\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=NC6(CCN(CC6)CCN7C(=NC=C7[N+](=O)[O-])C)N=C25)O)/C
InChI Key: OZUTUJQHZGJOKZ-AIGATTFSSA-N
Can. SMILES: C[C@H]1/C=C/C=C(/C)\C(=O)NC2=C(C3=C(C(=C4C(=C3C5=NC6(CCN(CC6)CCN7C(=NC=C7[N+](=O)[O-])C)N=C52)C(=O)[C@@](C)(O/C=C/[C@@H]([C@@H](C)[C@H]([C@H](C)[C@@H]([C@H](C)[C@H]1O)O)OC(=O)C)OC)O4)C)O)O
InChI: InChI=1S/C48H61N7O13/c1-23-12-11-13-24(2)46(62)50-38-37-36(51-48(52-37)15-17-53(18-16-48)19-20-54-29(7)49-22-32(54)55(63)64)33-34(42(38)60)41(59)28(6)44-35(33)45(61)47(9,68-44)66-21-14-31(65-10)25(3)43(67-30(8)56)27(5)40(58)26(4)39(23)57/h11-14,21-23,25-27,31,39-40,43,57-60H,15-20H2,1-10H3,(H,50,62)/b12-11+,21-14+,24-13-/t23-,25+,26+,27+,31-,39-,40+,43+,47-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/136014272
Guide to Pharmacology: rifasutenizol
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02045
Patent: WO2020078154

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