Compound ID | 2438

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2,4-Dibromo-3-chloro-1-hydroxyphenazine 29

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus and Enterococcus faecalis biofilms; binds to iron inducing iron starvation
Description: Synthetic compound (halogenated phenazine); several analogues with different antibacterial spectrum reported; selectivity index against mammalian cells >100
Institute where first reported: Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 402.47
Iso. SMILES: CC1=C2C(=CC=C1)N=C3C(=C(C(=C(C3=N2)Br)Cl)Br)O
InChI Key: GMDLASNAHBKIQT-UHFFFAOYSA-N
Can. SMILES: CC1=CC=CC2=NC3=C(C(=C(C(=C3N=C12)Br)Cl)Br)O
InChI: InChI=1S/C13H7Br2ClN2O/c1-5-3-2-4-6-10(5)18-11-7(14)9(16)8(15)13(19)12(11)17-6/h2-4,19H,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/165155798
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00168
Patent: US2022289689A1

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