Compound ID | 2443

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Xanthohumol derivative IV15

Synonym(s): GLXC-26719

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus; membrane-active agent
Description: Semisynthetic compound based on natural product xanthohumol from hop plant
Institute where first reported: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001 Henan Province, China
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 673.68
Iso. SMILES: CCCN(CCC)C(=O)C[N+](C)(C)CCCCOC1=CC=C(C=C1)/C=C/C(=O)C2=C(C=C3C(=C2O)C=CC(O3)(C)C)OC.[Br-]
InChI Key: BXNVBHYHXIFXMR-KLSJZZFUSA-N
Can. SMILES: CCCN(CCC)C(=O)C[N+](C)(C)CCCCOC1=CC=C(C=C1)/C=C/C(=O)C2=C(C=C3C(=C2O)C=CC(C)(C)O3)OC.[Br-]
InChI: InChI=1S/C35H48N2O6.BrH/c1-8-20-36(21-9-2)32(39)25-37(5,6)22-10-11-23-42-27-15-12-26(13-16-27)14-17-29(38)33-31(41-7)24-30-28(34(33)40)18-19-35(3,4)43-30;/h12-19,24H,8-11,20-23,25H2,1-7H3;1H/b17-14+;
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/167312319
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01793

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