Compound ID | 2444
12-mer α-helical peptide 8b
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Staphylococcus aureus, Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, Klebsiella pneumoniae; disrupts integrity of cytoplasmic membrane (membrane-active agent) |
| Description: | Synthetic compound; analogues reported; weakly cytotoxic to mammalian cells (HC50 at 280 ug/ml vs MIC at 3.1-12.5 ug/ml) |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01708 |
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