Compound ID | 2445
Peptide 5a
Synonym(s): 5a peptide
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against methicillin-resistant Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii; membrane-active agent |
| Description: | Synthetic compound; analogues reported; therapeutic index of 85 with mammalian cell HC50 at 340 ug/ml vs MIC at 2-32 ug/ml; synergistic effects with tetracycline, tobramycin, clindamycin, kanamycin, levofloxacin, polymyxin B, metronidazole, and vancomycin |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01469 |
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