Compound ID | 2446

Update compound information

Feleucin-K3 derived peptide K122

Synonym(s): GLXC-26528

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Membrane-active agent
Description: Synthetic compound; modified natural product feleucin-K3 from skin secretions of frog
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1276.46
Iso. SMILES: CC(C)C[C@@H](CN(CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N)S(=O)(=O)C1=CC=C(C=C1)I)N
InChI Key: NVOKNGPUZQRICQ-KDXYNCTASA-N
Can. SMILES: CC(C)C[C@@H](CN(CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N)S(=O)(=O)C1=CC=C(C=C1)I)N
InChI: InChI=1S/C56H102IN13O10S/c1-34(2)27-40(61)32-70(81(79,80)41-22-20-39(57)21-23-41)33-49(71)63-42(17-11-14-24-58)51(73)67-48(31-38(9)10)56(78)69-46(29-36(5)6)54(76)65-43(18-12-15-25-59)52(74)64-44(19-13-16-26-60)53(75)68-47(30-37(7)8)55(77)66-45(50(62)72)28-35(3)4/h20-23,34-38,40,42-48H,11-19,24-33,58-61H2,1-10H3,(H2,62,72)(H,63,71)(H,64,74)(H,65,76)(H,66,77)(H,67,73)(H,68,75)(H,69,78)/t40-,42-,43-,44-,45-,46-,47-,48-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/167312258
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01396

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