Compound ID | 2447

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Carbazole-oxadiazole 5g

Synonym(s): 1,3,4-Oxadiazole-2-thiol

Class: Membrane-active agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii; disrupts integrity of cytoplasmic membrane
Description: Synthetic compound; analogues reported; >40-60% cell viability of mammalian cells at 64 ug/ml (highest tested)
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 337.4
Iso. SMILES: C=CCOC1=CC=CC2=C1C3=CC=CC=C3N2CC4=NNC(=S)O4
InChI Key: MDXYUFZLNMNNTI-UHFFFAOYSA-N
Can. SMILES: C=CCOC1=CC=CC2=C1C3=CC=CC=C3N2CC4=NNC(=S)O4
InChI: InChI=1S/C18H15N3O2S/c1-2-10-22-15-9-5-8-14-17(15)12-6-3-4-7-13(12)21(14)11-16-19-20-18(24)23-16/h2-9H,1,10-11H2,(H,20,24)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/168290570
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00001

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