Compound ID | 2451

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N-Aryl-3-mercaptosuccinimide

Class: Antivirulence agent

Details of activity: Targets secreted metalloproteases LasB and ColH
Description: Synthetic compound; no cytotoxicity against mammalian cell line at 100 uM (highest tested); no antibacterial activity against Pseudomonas aeruginosa and Clostridium histolyticum; analogues reported
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 243.23
Iso. SMILES: FC1=CC(N2C(C(S)CC2=O)=O)=CC=C1F
InChI Key: ZRRHFNYFYYQRPE-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1)F)F)N2C(=O)CC(C2=O)S
InChI: InChI=1S/C10H7F2NO2S/c11-6-2-1-5(3-7(6)12)13-9(14)4-8(16)10(13)15/h1-3,8,16H,4H2
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00584

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