Compound ID | 2452

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Heteroaryl phosphonate compound 16

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Inhibits serine- and metallo-lactamases (KPC-2, NDM-1, and VIM-2)
Description: Synthetic compound; 88% mammalian cell viability at 100 ug/ml; potentiates imipenem
Year first mentioned: 2019
Development status: Experimental
Chemical structure(s):
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Molecular weight: 396.96
Iso. SMILES: C1=C(C=C(C2=C1NC(=O)C=C2CP(=O)(O)O)Br)Br
InChI Key: YMPWKSWKTYLHON-UHFFFAOYSA-N
Can. SMILES: C1=C(CP(=O)(O)O)C2=C(C=C(C=C2Br)Br)NC1=O
InChI: InChI=1S/C10H8Br2NO4P/c11-6-2-7(12)10-5(4-18(15,16)17)1-9(14)13-8(10)3-6/h1-3H,4H2,(H,13,14)(H2,15,16,17)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/139033900
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00728

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