Compound ID | 2458

Update compound information

Pyrrolo-imidazolone 18d

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa
Description: Synthetic compound
Institute where first reported: Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 433.48
Iso. SMILES: C[C@@](CCN1CC2=CC(=CN2C1=O)C#CC#CC3(CC3)CO)(C(=O)NO)S(=O)(=O)C
InChI Key: ROJCZRUQKASCDT-LJQANCHMSA-N
Can. SMILES: C[C@@](CCN1CC2=CC(=CN2C1=O)C#CC#CC3(CC3)CO)(C(=O)NO)S(=O)(=O)C
InChI: InChI=1S/C20H23N3O6S/c1-19(17(25)21-27,30(2,28)29)9-10-22-13-16-11-15(12-23(16)18(22)26)5-3-4-6-20(14-24)7-8-20/h11-12,24,27H,7-10,13-14H2,1-2H3,(H,21,25)/t19-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/129021462
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01604
Patent: EP3334737B1

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