Compound ID | 2459

Update compound information

(E)-3-(5-carboxy-2-fluorophenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one 73

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant Staphylococcus aureus with piperacillin-tazobactam; binds to PBP2a
Description: Synthetic compound; synergistic effect with piperacillin-tazobactam
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 411.39
Iso. SMILES: C1=CC=C2C(=C1)C(=O)N(C(=N2)/C=C/C3=CC=C(C=C3)C#N)C4=C(C=CC(=C4)C(=O)O)F
InChI Key: NBDRSERDBAXZSI-FMIVXFBMSA-N
Can. SMILES: C1=CC2=C(C=C1)N=C(/C=C/C3=CC=C(C=C3)C#N)N(C4=CC(=CC=C4F)C(=O)O)C2=O
InChI: InChI=1S/C24H14FN3O3/c25-19-11-10-17(24(30)31)13-21(19)28-22(12-9-15-5-7-16(14-26)8-6-15)27-20-4-2-1-3-18(20)23(28)29/h1-13H,(H,30,31)/b12-9+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/155520106
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00153

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