Omadacycline (Nuzyra)

Synonym(s): Omadacycline tosylate  |  PTK-0796

Class: Tetracycline

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Community-acquired bacterial pneumonia, acute bacterial skin and skin structure infections, complicated urinary tract infections
Description:	Semisynthetic minocycline derivative. Flamm. R., Rhomberg. P., huband. M., Farrell. D. "Activity of Omadacycline Tested Against Streptococcus pneumoniae from a Global Surveillance Program (2014) " Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy. 2015.
Institute where first reported:	Paratek Pharmaceuticals, USA
Year first mentioned:	2006
Highest developmental phase:	Approved by FDA in 2018
Development status:	Approved

Chemical structure(s):
Canonical SMILES:	CC(C)(C)CNCC1=CC(=C2C[C@H]3C[C@H]4[C@@H](C(=O)C(=C([C@]4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C
Isomeric SMILES:	CC(C)(C)CNCC1=CC(=C2C[C@H]3C[C@H]4[C@@H](C(=O)C(=C([C@]4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C
InChI:	InChI=1S/C29H40N4O7/c1-28(2,3)12-31-11-14-10-17(32(4)5)15-8-13-9-16-21(33(6)7)24(36)20(27(30)39)26(38)29(16,40)25(37)18(13)23(35)19(15)22(14)34/h10,13,16,21,31,34-35,38,40H,8-9,11-12H2,1-7H3,(H2,30,39)/t13-,16-,21-,29-/m0/s1
InChI Key:	VJYKVCURWJGLPG-IQZGDKDPSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/54697325

External links:
Guide to Pharmacology:	omadacycline
Main Source:	https://clinicaltrials.gov/ct2/results?cond=&term=Omadacycline&cntry1=&state1=&Search=Search
Citations:	http://aac.asm.org/content/58/3/1279.full http://paratekpharma.com/media/1161/craig2006icaacthigh-models.pdf https://www.ncbi.nlm.nih.gov/pubmed/30726689
Patent:	AU2021288202A1