Tideglusib and its analogues

Synonym(s): NP-12  |  NP031112  |  4-benzyl-2-(naphthalene-1-yl)-1,2,4-thiadiazolidine-3,5-dione

Class: Antivirulence agent (sortase inhibitor)

Spectrum of activity:	Gram-positive
Details of activity:	Active against Staphylococcus aureus
Description:	Synthetic compound; drug candidate for myotonic dystrophy; analogues reported
Year first mentioned:	2020
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	C1=CC=C(C=C1)CN2C(=O)N(C3=CC=CC4=C3C=CC=C4)SC2=O
Isomeric SMILES:	C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43
InChI:	InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
InChI Key:	PMJIHLSCWIDGMD-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/11313622

External links:
Main Source:	https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00803