Compound ID | 2461

Update compound information

Tideglusib and its analogues

Synonym(s): NP-12  |  NP031112  |  4-benzyl-2-(naphthalene-1-yl)-1,2,4-thiadiazolidine-3,5-dione

Class: Antivirulence agent

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus
Description: Synthetic compound; drug candidate for myotonic dystrophy; analogues reported
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 334.39
Iso. SMILES: C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43
InChI Key: PMJIHLSCWIDGMD-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)CN2C(=O)N(C3=CC=CC4=C3C=CC=C4)SC2=O
InChI: InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11313622
Guide to Pharmacology: tideglusib
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00803

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