Compound ID | 2463

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N-((1,3,6-trimethyl-4-oxo-1,4-dihydropyridin-2-yl)methyl)hexanamide 10d

Class: Antibiofilm agent

Spectrum of activity: Gram-negative
Details of activity: Active against Pseudomonas aeruginosa biofilm formation; inhibits quorum sensing and chelates iron
Description: Synthetic compound with 3-hydroxypyridin-4-one core; >50% mammalian cell viability at 100 uM (highest tested)
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 280.36
Iso. SMILES: CCCCCCC(=O)NCC1=C(C(=O)C=C(N1C)C)O
InChI Key: YGIPZKJXVNHJFG-UHFFFAOYSA-N
Can. SMILES: CCCCCCC(=O)NCC1=C(C(=O)C=C(C)N1C)O
InChI: InChI=1S/C15H24N2O3/c1-4-5-6-7-8-14(19)16-10-12-15(20)13(18)9-11(2)17(12)3/h9,20H,4-8,10H2,1-3H3,(H,16,19)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/141519871
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00763
Patent: CN108191746

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