Compound ID | 2472

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Thienopyrimidinone derivative

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Mycobacterium tuberculosis, and Acinetobacter baumannii; acts on TrmD and membrane-active agent
Description: Synthetic compound; only limited haemolytic activity at 100 uM (highest tested)
Year first mentioned: 2019
Development status: Experimental
Chemical structure(s):
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Molecular weight: 426.58
Iso. SMILES: [H]N(CCCCCCCC)CC1=CC=C(CNC(C2=CSC=3N=CNC(C32)=O)=O)C=C1
InChI Key: SZWXXUKSELBLQK-UHFFFAOYSA-N
Can. SMILES: CCCCCCCCN([H])CC1=CC=C(C=C1)CNC(=O)C2=CSC3=C2C(=O)NC=N3
InChI: InChI=1S/C23H30N4O2S/c1-2-3-4-5-6-7-12-24-13-17-8-10-18(11-9-17)14-25-21(28)19-15-30-23-20(19)22(29)26-16-27-23/h8-11,15-16,24H,2-7,12-14H2,1H3,(H,25,28)(H,26,27,29)
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00582

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