Compound ID | 2473

Update compound information

Pyrido[2,3-b]indole 17r

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli
Description: Synthetic compound; analogues reported
Institute where first reported: Department of Medicinal Chemistry, Roche Pharma Research and Early Development, Building 5, 720 Cailun Road, Shanghai 201203, China
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 500.45
Iso. SMILES: CCNC1=CC(=CC2=C1NC3=NC=C(C(=C23)N4C=C(C(=N4)C(F)(F)F)CN)C5=CN=C(N=C5)OC)F
InChI Key: TZIFVYPSLCLJGR-UHFFFAOYSA-N
Can. SMILES: CCNC1=C2C(=CC(=C1)F)C3=C(N=CC(=C3N4C=C(CN)C(=N4)C(F)(F)F)C5=CN=C(N=C5)OC)N2
InChI: InChI=1S/C23H20F4N8O/c1-3-29-16-5-13(24)4-14-17-19(35-10-11(6-28)20(34-35)23(25,26)27)15(9-30-21(17)33-18(14)16)12-7-31-22(36-2)32-8-12/h4-5,7-10,29H,3,6,28H2,1-2H3,(H,30,33)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/146646216
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00768
Patent: WO2020109191A1

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.