Corallopyronin A

Class: RNA polymerase inhibitor

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Active against Chlamydia sp., Corynebacterium mediolanum, Mycobacterium bovis, Staphylococcus aureus, and Wolbachia sp.
Description:	Natural product from Corallococcus (=Myxococcus=Chondrococcus) coralloides strain Cc127 (DSM 2550)
Institute where first reported:	Univ. of Leeds, UK; Institute for Pharmaceutical Biology, University of Bonn, Germany
Year first mentioned:	1985
Highest developmental phase:	Preclinical
Development status:	Inactive
Reason Dropped:	Selects for resistance (7.2E-8) and has minimal activity, it was suggested this may be a potential scaffold for investigation and optimisation.

Chemical structure(s):
Canonical SMILES:	C/C=C/C/C=C(\C)/C(CC/C(=C/C=C(\C)/C(=O)C1=C(C=C(C(C)CC/C=C/NC(=O)OC)OC1=O)O)/C)O
Isomeric SMILES:	C/C=C/C/C=C(\C)/C(CC/C(=C/C=C(\C)/C(=O)C1=C(C=C(OC1=O)C(C)CC/C=C/NC(=O)OC)O)/C)O
InChI:	InChI=1S/C30H41NO7/c1-7-8-9-12-21(3)24(32)17-15-20(2)14-16-23(5)28(34)27-25(33)19-26(38-29(27)35)22(4)13-10-11-18-31-30(36)37-6/h7-8,11-12,14,16,18-19,22,24,32-33H,9-10,13,15,17H2,1-6H3,(H,31,36)/b8-7+,18-11+,20-14+,21-12+,23-16+
InChI Key:	FPBHSTHTCPCNBS-QXMYDWGFSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/135570663

External links:
Main Source:	https://pubs.rsc.org/en/content/articlepdf/2022/np/d2np00012a
Citation:	https://www.jstage.jst.go.jp/article/antibiotics1968/38/2/38_2_145/_pdf/-char/en
Patent:	EP2704708B1