Compound ID | 2479

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Desotamide A

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus and Streptococcus pneumoniae; reported to inhibit RNA synthesis
Description: Natural product from marine-isolated Streptomyces scopuliridis SCSIO ZJ46; not cytotoxic to mammalian cell lines (IC50 > 100uM)
Year first mentioned: 2014
Development status: Experimental
Chemical structure(s):
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Molecular weight: 696.84
Iso. SMILES: CC[C@@H](C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)CC(C)C)CC(C)C)CC2=CNC3=CC=CC=C32)CC(=O)N
InChI Key: LJGXNPVJAKBNOK-DTWKRICWSA-N
Can. SMILES: CC[C@@H](C)[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N1
InChI: InChI=1S/C35H52N8O7/c1-7-20(6)30-35(50)42-27(15-28(36)44)31(46)38-17-29(45)39-26(14-21-16-37-23-11-9-8-10-22(21)23)33(48)40-24(12-18(2)3)32(47)41-25(13-19(4)5)34(49)43-30/h8-11,16,18-20,24-27,30,37H,7,12-15,17H2,1-6H3,(H2,36,44)(H,38,46)(H,39,45)(H,40,48)(H,41,47)(H,42,50)(H,43,49)/t20-,24+,25-,26+,27+,30+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/181446
Citations:
  • https://www.mdpi.com/1660-3397/19/6/303
  • https://www.mdpi.com/2079-6382/9/8/452
  • https://pubs.acs.org/doi/10.1021/np500399v

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