Compound ID | 249

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Benzothiazole Ethyl Urea Inhibitor Compound A

Class: Bacterial topoisomerase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Staphylococcus aureus Streptococcus pneumoniae, enterococci and Clostridium difficile
Institute where first reported: Biota Europe Ltd., UK
Year first mentioned: 2013
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 503.58
Iso. SMILES: OC(C1CCN(C2=NC=C(C3=CC4=C(SC(NC(NCC)=O)=N4)C(C5=CC=CC=N5)=C3)C=N2)CC1)=O
InChI Key: RPPRAYQNSDDYNW-UHFFFAOYSA-N
Can. SMILES: CCNC(=O)NC1=NC2=C(C(=CC(=C2)C3=CN=C(N=C3)N4CCC(CC4)C(=O)O)C5=NC=CC=C5)S1
InChI: InChI=1S/C25H25N7O3S/c1-2-26-24(35)31-25-30-20-12-16(11-18(21(20)36-25)19-5-3-4-8-27-19)17-13-28-23(29-14-17)32-9-6-15(7-10-32)22(33)34/h3-5,8,11-15H,2,6-7,9-10H2,1H3,(H,33,34)(H2,26,30,31,35)
External links:
Citations:
  • http://aac.asm.org/content/57/12/5977.full
  • https://journals.asm.org/doi/full/10.1128/aac.00719-13

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