Compound ID | 2494
Symbah-1
Class: Antimicrobial peptide
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Membrane-active agent. Disrupts integrity of inner and outer bacterial membrane |
| Target Pathogen: | Active against ESKAPE pathogens |
| Description: | Synthetic compound identified from surface localized antimicrobial display; a macrocyclic β-hairpin antibiotic peptide (symbah-1); selective against human erythrocytes; variants reported |
| Year first mentioned: | 2021 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.cell.com/iscience/fulltext/S2589-0042(21)01581-9 |
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