Compound ID | 2499

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Ruthenium red

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Klebsiella pneumoniae
Description: Synthetic cationic dye identified from screening the McMaster collection for compounds with activity in human serum (serum-enhanced antibacterial compounds); other hits reported (MAC-0451323, MAC-0414791, MAC-0357499, and MAC-0321397); showed potent low MIC in serum but not in media; poor pharmacokinetics
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 790.37
Iso. SMILES: N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].[Ru+2]
InChI Key: JQJSTVUROJELSR-UHFFFAOYSA-H
Can. SMILES: [Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Ru+2].[Ru+2].[Ru+2]
InChI: InChI=1S/6ClH.14H3N.2H2O.3Ru/h6*1H;14*1H3;2*1H2;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/16218584
Citation: https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30908-6

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