Compound ID | 2500

Update compound information

Armeniaspirol A

Class: Antivirulence agent

Agent Type: Natural product; Small molecule; Indirect acting; Antivirulence;
Spectrum of activity: Gram-positive
Mechanism of action: Inhibits ClpXP and ClpYQ
Target Pathogen: Active against methicillin-resistant and -susceptible Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis
Description: Natural product from Streptomyces armeniacus
Year first mentioned: 2012
Development status: Experimental
Chemical structure(s):
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Molecular weight: 384.25
Iso. SMILES: CCCCCCC1=C(C=CC2=C1O[C@]3(C2=O)C(=C(C(=O)N3C)Cl)Cl)O
InChI Key: ZSUZJBBHPTXKIV-SFHVURJKSA-N
Can. SMILES: CCCCCCC1=C2C(=CC=C1O)C(=O)[C@]3(C(=C(C(=O)N3C)Cl)Cl)O2
InChI: InChI=1S/C18H19Cl2NO4/c1-3-4-5-6-7-10-12(22)9-8-11-14(10)25-18(16(11)23)15(20)13(19)17(24)21(18)2/h8-9,22H,3-7H2,1-2H3/t18-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/58534983
Citations:
  • https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.201201635
  • https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(21)00311-1

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