Compound ID | 2504

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Chlorotonil A

Class: Macrolide

Spectrum of activity: Gram-positive
Details of activity: Active against Clostridioides difficile
Description: Natural product from myxobacterium Sorangium cellulosum; low systemic bioavailability
Year first mentioned: 2007
Development status: Experimental
Chemical structure(s):
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Molecular weight: 479.44
Iso. SMILES: C[C@@H]1/C=C\C=C\[C@@H](OC(=O)[C@H](C(=O)C(C(=O)[C@@H]2[C@H]1C=C[C@H]3[C@H]2[C@@H](C=C(C3)C)C)(Cl)Cl)C)C
InChI Key: RQYZFUUTQJMTMJ-JCSZEPHKSA-N
Can. SMILES: CC1=C[C@@H](C)[C@@H]2[C@H](C=C[C@H]3[C@H](C)/C=C\C=C\[C@H](C)OC(=O)[C@@H](C)C(=O)C(C(=O)[C@H]32)(Cl)Cl)C1
InChI: InChI=1S/C26H32Cl2O4/c1-14-12-16(3)21-19(13-14)10-11-20-15(2)8-6-7-9-17(4)32-25(31)18(5)23(29)26(27,28)24(30)22(20)21/h6-12,15-22H,13H2,1-5H3/b8-6-,9-7+/t15-,16-,17+,18+,19-,20+,21-,22-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/24742044
Guide to Pharmacology: chlorotonil A
Citations:
  • https://onlinelibrary.wiley.com/doi/10.1002/anie.200703993
  • https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00147-6

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