Chlorotonil A

Class: Macrolide

Spectrum of activity:	Gram-positive
Details of activity:	Active against Clostridioides difficile
Description:	Natural product from myxobacterium Sorangium cellulosum; low systemic bioavailability
Year first mentioned:	2007
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC1=C[C@@H](C)[C@@H]2[C@H](C=C[C@H]3[C@H](C)/C=C\C=C\[C@H](C)OC(=O)[C@@H](C)C(=O)C(C(=O)[C@H]32)(Cl)Cl)C1
Isomeric SMILES:	C[C@@H]1/C=C\C=C\[C@@H](OC(=O)[C@H](C(=O)C(C(=O)[C@@H]2[C@H]1C=C[C@H]3[C@H]2[C@@H](C=C(C3)C)C)(Cl)Cl)C)C
InChI:	InChI=1S/C26H32Cl2O4/c1-14-12-16(3)21-19(13-14)10-11-20-15(2)8-6-7-9-17(4)32-25(31)18(5)23(29)26(27,28)24(30)22(20)21/h6-12,15-22H,13H2,1-5H3/b8-6-,9-7+/t15-,16-,17+,18+,19-,20+,21-,22-/m1/s1
InChI Key:	RQYZFUUTQJMTMJ-JCSZEPHKSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/24742044

External links:
Guide to Pharmacology:	chlorotonil A
Main Source:	https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00147-6
Citation:	https://onlinelibrary.wiley.com/doi/10.1002/anie.200703993