Compound ID | 2506

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Quinazolinone 34

Class: Antivirulence agent

Agent Type: Synthetic; Small molecule; Direct acting; Indirect acting; Antivirulence;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Membrane-active agent. Acts as membrane-active agent in Gram-positives
Target Pathogen: Active against Pseudomonas aeruginosa and Staphylococcus aureus
Description: Synthetic compound; eradicates mixed-species biofilm when combined with aminoglycoside antibiotic; analogues reported
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 363.93
Iso. SMILES: CCCCCCCCCC1=NC2=C(C=CC(=C2)Cl)C(=O)N1CCCN
InChI Key: BSGSJJDZHCCWCT-UHFFFAOYSA-N
Can. SMILES: CCCCCCCCCC1=NC2=C(C=CC(=C2)Cl)C(=O)N1CCCN
InChI: InChI=1S/C20H30ClN3O/c1-2-3-4-5-6-7-8-10-19-23-18-15-16(21)11-12-17(18)20(25)24(19)14-9-13-22/h11-12,15H,2-10,13-14,22H2,1H3
External links:
Citation: https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(22)00088-5

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