Compound ID | 2508

Update compound information

Enterocin A, Enterocin B

Class: Antimicrobial peptide

Agent Type: Natural product; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent
Target Pathogen: Active against methicillin-resistant Staphylococcus aureus, Streptococcus mutans, and Streptococcus pyogenes
Description: Natural product from Enterococcus faecium NT04 (also by Streptomyces hygroscopicus identified as vulgamycin); bacteriocin-type
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1111.17
Iso. SMILES: CC(C(C(=O)NC(C(C)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NCC(=O)NC(CC(=O)N)C=O)N)O
InChI Key: UDJYWZUEIHCKKJ-UHFFFAOYSA-N
Can. SMILES: CC(C(C(=O)NC(C(C)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NCC(=O)NC(CC(=O)N)C=O)N)O
InChI: InChI=1S/C49H70N14O16/c1-25(66)41(52)48(78)63-42(26(2)67)49(79)61-36(17-29-19-53-24-56-29)47(77)62-37(23-65)44(74)55-21-40(72)58-33(5-3-4-14-50)45(75)60-35(16-28-8-12-32(69)13-9-28)46(76)59-34(15-27-6-10-31(68)11-7-27)43(73)54-20-39(71)57-30(22-64)18-38(51)70/h6-13,19,22,24-26,30,33-37,41-42,65-69H,3-5,14-18,20-21,23,50,52H2,1-2H3,(H2,51,70)(H,53,56)(H,54,73)(H,55,74)(H,57,71)(H,58,72)(H,59,76)(H,60,75)(H,61,79)(H,62,77)(H,63,78)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/139587481
Citation: https://www.cell.com/heliyon/fulltext/S2405-8440(23)03460-6

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