Compound ID | 2509

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JCP276

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Lipopolysaccharide synthesis inhibitor. Targets multiple serine hydrolases leading to accumulation of free lipids and decrease in lipopolysaccharide
Target Pathogen: Active against Mycobacterium tuberculosis
Description: Synthetic compound identified from screening of molecules with cysteine- and serine-reactive electrophiles that inhibit M. tuberculosis growth
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 451.7
Iso. SMILES: C1=CC=C(C=C1)NC(=O)NC2=CC3=C(C=C2)C(=C(OC3=O)OCCCBr)Cl
InChI Key: NOUCBQBZTFYQQV-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)NC(=O)NC2=CC3=C(C=C2)C(=C(OCCCBr)OC3=O)Cl
InChI: InChI=1S/C19H16BrClN2O4/c20-9-4-10-26-18-16(21)14-8-7-13(11-15(14)17(24)27-18)23-19(25)22-12-5-2-1-3-6-12/h1-3,5-8,11H,4,9-10H2,(H2,22,23,25)
External links:
Citation: https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(21)00402-5

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