Compound ID | 2510

Update compound information

Loratadine

Class: Antivirulence agent

Agent Type: Synthetic; Small molecule; Indirect acting; Antivirulence; Antibiofilm;
Spectrum of activity: Gram-positive
Mechanism of action: Targets biofilm formation and inhibits expression of virulence factors
Target Pathogen: Active against Staphylococcus aureus
Description: Synthetic compound; FDA-approved antihistamine; synergistic effect with vancomycin
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 382.88
Iso. SMILES: CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
InChI Key: JCCNYMKQOSZNPW-UHFFFAOYSA-N
Can. SMILES: CCOC(=O)N1CCC(=C2C3=C(CCC4=CC=CN=C42)C=C(C=C3)Cl)CC1
InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3957
Citation: https://www.cell.com/iscience/fulltext/S2589-0042(22)00001-3

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