Compound ID | 2517
Titanium/Hydroxyapatite
Class: Small molecule antibacterial agent
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Streptococcus pyogenes; TiO2 penetrates cytoplasm creating ionic conditions that prevent ATP formation and DNA replication |
| Description: | Synthetic material (nanocomposite); >70% NIH3T3 cell viability at highest concentration tested (250 ug/ml) |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.cell.com/heliyon/fulltext/S2405-8440(23)01641-9 |
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