Compound ID | 2525

Update compound information

Amoxapine

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus
Description: Synthetic compound; FDA-approved tetracyclic antidepressant; resensitizes S. aureus to oxacillin; no complete inhibition on its own even at high concentration
Year first mentioned: 2018
Development status: Experimental
Chemical structure(s):
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Molecular weight: 313.78
Iso. SMILES: C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
InChI Key: QWGDMFLQWFTERH-UHFFFAOYSA-N
Can. SMILES: C1=CC=C2C(=C1)N=C(C3=C(C=CC(=C3)Cl)O2)N4CCNCC4
InChI: InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/2170
Citation: https://www.cell.com/heliyon/fulltext/S2405-8440(17)33004-9

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