Compound ID | 253

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Gepotidacin

Synonym(s): GSK2140944

Class: Bacterial topoisomerase inhibitor

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Treatment of conventional and biothreat pathogens including MRSA. Respiratory tract infections, acute bacterial skin and skin structure infections (ABSSI), uncomplicated urogenital gonorrhoea
Institute where first reported: GlaxoSmithKline, UK
Year first mentioned: 2011
Highest developmental phase: Phase 3
Development status: Active
Chemical structure(s):
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Molecular weight: 448.52
Iso. SMILES: C1CC2=CC(=NC=C2OC1)CNC3CCN(CC3)C[C@@H]4CN5C(=O)C=CC6=C5N4C(=O)C=N6
InChI Key: PZFAZQUREQIODZ-LJQANCHMSA-N
Can. SMILES: C1CC2=C(C=NC(=C2)CNC3CCN(CC3)C[C@@H]4CN5C(=O)C=CC6=C5N4C(=O)C=N6)OC1
InChI: InChI=1S/C24H28N6O3/c31-22-4-3-20-24-29(22)15-19(30(24)23(32)13-27-20)14-28-7-5-17(6-8-28)25-11-18-10-16-2-1-9-33-21(16)12-26-18/h3-4,10,12-13,17,19,25H,1-2,5-9,11,14-15H2/t19-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/25101874
Guide to Pharmacology: gepotidacin
Citations:
  • https://clinicaltrials.gov/ct2/show/NCT02045797
  • https://www.gsk-clinicalstudyregister.com/search/?search_terms=GSK2140944
    • Patent: WO2021219637A1

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