Compound ID | 2534

Update compound information

Bottromycin A2

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Mycobacterium sp., and Escherichia coli; inhibits protein synthesis
Description: Natural product from soil Streptomyces bottropensis; a macrocyclic peptide
Year first mentioned: 1955
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Instability in oral and parenteral administration
Chemical structure(s):
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Molecular weight: 823.06
Iso. SMILES: CC1CCN2C1C(=O)NC(C(=O)NC(C(=NCC2=O)NC(C(=O)NC(C(C)C3=CC=CC=C3)C(=O)NC(CC(=O)OC)C4=NC=CS4)C(C)(C)C)C(C)(C)C)C(C)C
InChI Key: KSIZLOPUXFSFNR-UHFFFAOYSA-N
Can. SMILES: CC(C)C1C(=O)NC(C(=NCC(=O)N2CCC(C)C2C(=O)N1)NC(C(=O)NC(C(C)C3=CC=CC=C3)C(=O)NC(CC(=O)OC)C4=NC=CS4)C(C)(C)C)C(C)(C)C
InChI: InChI=1S/C42H62N8O7S/c1-23(2)30-36(53)49-33(41(5,6)7)35(44-22-28(51)50-19-17-24(3)32(50)38(55)46-30)48-34(42(8,9)10)39(56)47-31(25(4)26-15-13-12-14-16-26)37(54)45-27(21-29(52)57-11)40-43-18-20-58-40/h12-16,18,20,23-25,27,30-34H,17,19,21-22H2,1-11H3,(H,44,48)(H,45,54)(H,46,55)(H,47,56)(H,49,53)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3081434
Citation: https://pubs.rsc.org/en/content/articlelanding/2021/np/d0np00097c

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