Compound ID | 2537

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Brevistin

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae
Description: Natural product from Bacillus brevis 342-1
Year first mentioned: 1975
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1346.49
Iso. SMILES: O=C1OC(C(NC(=O)CCCCC(CC)C)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(NCC(NC(C(NC(C(NC(C(NC1CC2=CC=CC=C2)=O)CCN)=O)C(CC)C)=O)CC=3NC=4C=CC=CC4C3)=O)=O)CC(=O)O)CC(=O)N)CC(=O)O)CCN)C
InChI Key: UTZGLRKJAFLPQM-UHFFFAOYSA-N
Can. SMILES: CCC(C)CCCCC(=O)NC1C(C)OC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC(=O)C(C(C)CC)NC(=O)C(CC3=CC4=C(C=CC=C4)N3)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(CC(=O)N)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(CCN)NC1=O
InChI: InChI=1S/C63H91N15O18/c1-6-33(3)15-11-14-20-48(80)77-54-35(5)96-63(95)46(25-36-16-9-8-10-17-36)76-58(90)41(22-24-65)72-61(93)53(34(4)7-2)78-60(92)42(27-38-26-37-18-12-13-19-39(37)69-38)70-49(81)31-67-56(88)45(30-52(85)86)75-59(91)43(28-47(66)79)71-50(82)32-68-55(87)44(29-51(83)84)74-57(89)40(21-23-64)73-62(54)94/h8-10,12-13,16-19,26,33-35,40-46,53-54,69H,6-7,11,14-15,20-25,27-32,64-65H2,1-5H3,(H2,66,79)(H,67,88)(H,68,87)(H,70,81)(H,71,82)(H,72,93)(H,73,94)(H,74,89)(H,75,91)(H,76,90)(H,77,80)(H,78,92)(H,83,84)(H,85,86)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/85422287
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/29/4/29_4_380/_pdf/-char/en
  • https://www.jstage.jst.go.jp/article/antibiotics1968/29/4/29_4_375/_pdf/-char/en

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