Diazoquinomycin H

Class: DNA synthesis inhibitor

Spectrum of activity:	Gram-positive
Details of activity:	Active against Mycobacterium tuberculosis and non-tuberculous Mycobacterium, methicillin-susceptible Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium
Description:	Natural product from Streptomyces sp. OM-704; no cytotoxicity against Vero cells at 28 uM vs 0.04-0.1 ug/ml MIC
Year first mentioned:	1982
Development status:	Inactive
Reason Dropped:	Poor aqueous solubility

Chemical structure(s):
Canonical SMILES:	CC(C)CCCCCCC1=CC(=O)NC2=C1C(=O)C3=C(C2=O)NC(=O)C=C3C
Isomeric SMILES:	CC1=CC(=O)NC2=C1C(=O)C3=C(C2=O)NC(=O)C=C3CCCCCCC(C)C
InChI:	InChI=1S/C22H26N2O4/c1-12(2)8-6-4-5-7-9-14-11-16(26)24-20-18(14)21(27)17-13(3)10-15(25)23-19(17)22(20)28/h10-12H,4-9H2,1-3H3,(H,23,25)(H,24,26)
InChI Key:	ZMMKQTMMGUIIJM-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/134815171

External links:
Main Source:	https://pubs.acs.org/doi/10.1021/acsinfecdis.5b00005
Citation:	https://pubmed.ncbi.nlm.nih.gov/3840154/